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Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0
Metformin has been widely used as a first-line anti-diabetic medicine for the treatment of type 2 diabetes (T2D). As a drug that primarily targets the liver, metformin suppresses hepatic glucose production (HGP), serving as the main mechanism by which metformin improves hyperglycemia of T2D. Biochemically, metformin suppresses gluconeogenesis and stimulates glycolysis. Metformin also inhibits glycogenolysis, which is a pathway that critically contributes to elevated HGP. While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and corrects dyslipidemia in patients with T2D. These beneficial effects of metformin implicate a role for metformin in managing non-alcoholic fatty liver disease. As supported by the results from both human and animal studies, metformin improves hepatic steatosis and suppresses liver inflammation. Mechanistically, the beneficial effects of metformin on hepatic aspects are mediated through both adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. In addition, metformin is generally safe and may also benefit patients with other chronic liver diseases.
Keywords: metformin diabetes hepatic steatosis inflammatory response insulin resistance
C. RENNO, A. PERONE
Frontiers in Energy 2021, Volume 15, Issue 2, Pages 384-395 doi: 10.1007/s11708-020-0717-9
Keywords: CPV system point-focus experimental model energy and economic analysis
Review of aeroelasticity for wind turbine: Current status, research focus and future perspectives
Pinting ZHANG, Shuhong HUANG
Frontiers in Energy 2011, Volume 5, Issue 4, Pages 419-434 doi: 10.1007/s11708-011-0166-6
Keywords: wind turbine aeroelasticity aeroelastic code
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 6, doi: 10.1007/s11783-023-1666-4
● A global snapshot of plastic waste generation and disposal is analysed.
Keywords: Plastic waste Farmlands Terrestrial ecosystem Marine life
Xiliang ZHANG, Zhiying CUI, Jianhan ZHANG, Fengwu BAI, Zhifeng WANG
Frontiers in Energy 2019, Volume 13, Issue 3, Pages 590-596 doi: 10.1007/s11708-018-0602-y
Keywords: secondary parabolic trough solar concentrator ray tracing method linear focus concentration ratio optical
Frontiers of Engineering Management 2022, Volume 9, Issue 2, Pages 177-195 doi: 10.1007/s42524-021-0184-y
Keywords: blockchain construction project smart contract smart payment payment dispute
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Frontiers of Medicine doi: 10.1007/s11684-023-1037-3
Keywords: COVID-19 antiviral drugs mindeudesivir
Ping Sheng
Engineering 2021, Volume 7, Issue 5, Pages 552-553 doi: 10.1016/j.eng.2021.02.003
Uwe LUDEWIG, Lixing YUAN, Günter NEUMANN
Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 4, Pages 357-365 doi: 10.15302/J-FASE-2019275
Phosphorus (P) is essential for life and for efficient crop production, but global P use with limited recycling is inefficient in several sectors, including agronomy. Unfortunately, plant physiologists, agronomists, farmers and end users employ different measures for P use efficiency (PUE), which often masks their values at different scales. The term P use effectiveness, which also considers energetic and sustainability measures in addition to P balances, is also a valuable concept. Major physiological and genetic factors for plant P uptake and utilization have been identified, but there has been limited success in genetically improving PUE of modern crop cultivars. In maize, studies on root architectural and morphological traits appear promising. Rhizosphere processes assist in mobilizing and capturing sparingly soluble phosphate from rock phosphate. Combinations of phosphate-solubilizing microorganisms with ammonium-based nitrogen fertilizer, as well as strategies of fertilizer placement near the roots of target crops, can moderately enhance PUE. The desired concentration of P in the products differs, depending on the final use of the crop products as feed, food or for energy conversion, which should be considered during crop production.
Keywords: acquisition efficiency plant growth promoting rhizobacteria phosphate use efficiency utilization efficiency
FOR USE IN AGROECOSYSTEM IMPROVEMENT IN SEMI-ARID AREAS WITH A FOCUS ON CENTRAL ANATOLIA, TURKEY
Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 4, Pages 568-582 doi: 10.15302/J-FASE -2019270
Keywords: actinorrhizal trees / agroforestry / climate change / ecosystem restoration
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 231-241 doi: 10.1007/s11684-013-0253-7
Keywords: liver cancer epigenetics histone modifications polycomb group proteins enhancer of zeste homolog 2 (EZH2)
A full-process intelligent trial system for smart court Research Articles
Bin WEI, Kun KUANG, Changlong SUN, Jun FENG, Yating ZHANG, Xinli ZHU, Jianghong ZHOU, Yinsheng ZHAI, Fei WU,srsysj@zju.edu.cn,kunkuang@zju.edu.cn,changlong.scl@taobao.com,JuneFeng.81@gmail.com,wufei@zju.edu.cn
Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 2, Pages 186-206 doi: 10.1631/FITEE.2100041
Keywords: Intelligent trial system Smart court Evidence analysis Dialogue summarization Focus of controversy
Controversy on design science and competitiveness of design
Xie Youbai
Strategic Study of CAE 2014, Volume 16, Issue 8, Pages 4-13
The controversy on ‘design science’ since the end of 19
Keywords:
design
industrial design
design science
knowledge
knowledge acquirement
Hydrogen Power Focus Shifts from Cars to Heavy Vehicles
Chris Palmer
Engineering 2020, Volume 6, Issue 12, Pages 1333-1335 doi: 10.1016/j.eng.2020.10.006
Lei Zheng, Xingbao Gao, Wei Wang, Zifu Li, Lingling Zhang, Shikun Cheng
Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 1, doi: 10.1007/s11783-019-1184-6
Keywords: MSWI fly ash Cementing efficiency Health risk assessment of heavy metal Sand replacement Cement replacement
Title Author Date Type Operation
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Journal Article
Energy and economic analysis of a point-focus concentrating photovoltaic system when its installation
C. RENNO, A. PERONE
Journal Article
Review of aeroelasticity for wind turbine: Current status, research focus and future perspectives
Pinting ZHANG, Shuhong HUANG
Journal Article
Current scenario and challenges of plastic pollution in Bangladesh: a focus on farmlands and terrestrial
Journal Article
Optical performance analysis of an innovative linear focus secondary trough solar concentrating system
Xiliang ZHANG, Zhiying CUI, Jianhan ZHANG, Fengwu BAI, Zhifeng WANG
Journal Article
Blockchain-based smart contract for smart payment in construction: A focus on the payment freezing and
Journal Article
Small-molecule anti-COVID-19 drugs and a focus on China’s homegrown mindeudesivir (VV116)
Journal Article
Improving the efficiency and effectiveness of global phosphorus use: focus on root and rhizosphere levels
Uwe LUDEWIG, Lixing YUAN, Günter NEUMANN
Journal Article
FOR USE IN AGROECOSYSTEM IMPROVEMENT IN SEMI-ARID AREAS WITH A FOCUS ON CENTRAL ANATOLIA, TURKEY
Journal Article
Epigenetic dysregulation in hepatocellular carcinoma: focus on polycomb group proteins
Sandy Leung-Kuen Au, Irene Oi-Lin Ng, Chun-Ming Wong
Journal Article
A full-process intelligent trial system for smart court
Bin WEI, Kun KUANG, Changlong SUN, Jun FENG, Yating ZHANG, Xinli ZHU, Jianghong ZHOU, Yinsheng ZHAI, Fei WU,srsysj@zju.edu.cn,kunkuang@zju.edu.cn,changlong.scl@taobao.com,JuneFeng.81@gmail.com,wufei@zju.edu.cn
Journal Article